Dead cells collector3/27/2023 ![]() ![]() 12, 13 DDSs can efficiently target a specific living tissue and promote drug absorption. 11 In recent years, the research on DDSs has focused on enhancing the carrier's release kinetic, incorporating different techniques to produce new generations of carriers. ![]() 10 An ideal drug carrier should have the following characteristics: stable physical and chemical properties, biocompatibility, extremely low toxicity, and adjustable drug release. 9 The DDS optimization also avoids burst release reducing the side effects of high concentrations of drugs. Additionally, the carriers can maintain an effective drug concentration for the designated period. 8 By taking advantage of controlled releasing carriers as DDSs, the drug molecules could be sustainably released. 7 In this process, a polymer, ceramic, or metal carrier is combined with a drug or active agent in a designed approach so that an active agent can be released into the human body in a predetermined and desired way. 4- 6 Controlled drug release is one of the methods of drug delivery and an essential topic in biomedical research. 3 Hence, DDSs have grown in importance in the pharmacological industry over the past few decades. 1, 2 Scientific discoveries revealed that controlled delivery of drugs could affect treatment efficacy. The strategy of providing medication or other pharmacological substances to produce a long-lasting therapeutic effect is realized with drug delivery systems (DDSs). Investigations into the photo-responsive release mechanism demonstrate the system's potential as a “smart” drug delivery platform. The presence of plasmonic nanoparticles enables the platform to twice the amount of drug release besides exhibiting a long-term release. The fabricated nanofibers have a hydrophilic PVA and Rhodamine-B (RhB) core, while the shell is hydrophobic PLGA decorated with gold nanorods (Au NRs). A coaxial electrospinning setup paired with an electrospraying technique is used to fabricate core-shell PVA-PLGA nanofibers decorated with plasmonic nanoparticles. ![]() Furthermore, it can provide a sustained release profile and prevent burst release and high concentrations of drugs. The photo-responsivity of the platform enables on-demand elevated drug release. In this study, we developed an electrospun nanofibrous photo-responsive DDSs. Nanoplatforms can enhance drug release efficacy while reducing the side effects of drugs by taking advantage of the responses to specific internal or external stimuli. Recent advancements in biomedical nanotechnology resulted in introducing stimuli-responsiveness to drug vehicles. Over the last few years, traditional drug delivery systems (DDSs) have been transformed into smart DDSs. ![]()
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